RapamycinFungusV1, Main, Exploration, bibRecord, 000A24

Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.

Identifieur interne : 000A24 ( Main/Exploration ); précédent : 000A23; suivant : 000A25

Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.

Auteurs : Astrid Hernández-Sierra [Espagne] ; Jordi Rovira [Espagne] ; Anna Petit [Espagne] ; Daniel Moya-Rull [Espagne] ; María Auxiliadora Mazuecos [Espagne] ; Ana Isabel Sánchez-Fructuoso [Espagne] ; Pedro Errasti [Espagne] ; Miguel Ngel Idoate [Espagne] ; Josep María Cruzado [Espagne] ; August Vidal [Espagne] ; Fritz Diekmann [Espagne] ; Federico Oppenheimer [Espagne] ; Josep M. Campistol [Espagne] ; Ignacio Revuelta [Espagne]

Source :

Transplant international : official journal of the European Society for Organ Transplantation [ 1432-2277 ] ; 2016.

RBID : pubmed:27208691

Descripteurs français

English descriptors

KwdEn :
- Aged (MeSH), Female (MeSH), Graft Survival (MeSH), Herpesvirus 8, Human (MeSH), Humans (MeSH), Immunosuppression (MeSH), Immunosuppressive Agents (therapeutic use), Kidney Transplantation (MeSH), Male (MeSH), Middle Aged (MeSH), Multivariate Analysis (MeSH), Neoplasm Recurrence, Local (MeSH), Neoplasm Staging (methods), PTEN Phosphohydrolase (metabolism), Ribosomal Protein S6 Kinases, 70-kDa (metabolism), Sarcoma, Kaposi (metabolism), Sarcoma, Kaposi (virology), Spain (MeSH), TOR Serine-Threonine Kinases (metabolism), Time Factors (MeSH), Transforming Growth Factor beta (metabolism), Vascular Endothelial Growth Factor A (metabolism).
MESH :
- chemical , metabolism : PTEN Phosphohydrolase, Ribosomal Protein S6 Kinases, 70-kDa, TOR Serine-Threonine Kinases, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A.
- chemical , therapeutic use : Immunosuppressive Agents.
- metabolism : Sarcoma, Kaposi.
- methods : Neoplasm Staging.
- virology : Sarcoma, Kaposi.
- Aged, Female, Graft Survival, Herpesvirus 8, Human, Humans, Immunosuppression, Kidney Transplantation, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Spain, Time Factors.

Abstract

Kaposi's sarcoma (KS) is one of the most frequent transplant related tumors. Several pathways are involved; however, the impact of the molecular phenotype associated to the tumor stage and the behavior-depending resultant therapy is still unknown. The aim of our study was to analyze the role of HHV-8 and mTOR pathway in tumor stages of skin KS after renal transplantation. Twelve renal transplant recipients with cutaneous KS from five transplant centers (1980-2007) under reduction of immunosuppression or conversion to mTOR inhibitor were included. The expression of HHV-8, PTEN, TGFβ, VEGF, phospho-mTOR, and phospho-P70S6K in tumoral tissue was analyzed. KS lesions were classified as patch, plaque, and nodule state. HHV-8 infection was found in all tissue samples. KS lesions showed high activation of VEGF, p-mTOR and p-P70S6K, low PTEN, and null TGFβ expression. The only pathway activated in a staging-dependent manner was mTOR with higher p-mTOR and p-P70S6K expression in nodule versus patch stage. KS lesions disappeared after 5.24 months in all converted patients without any recurrence in 14.05 years of mean follow-up. The activation of mTOR pathway according to KS stages supports the rational of the mTOR inhibitor in post-transplant Kaposi.

DOI: 10.1111/tri.12800
PubMed: 27208691

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000A49
to stream Main, to step Curation: 000A49

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.</title>
<author><name sortKey="Hernandez Sierra, Astrid" sort="Hernandez Sierra, Astrid" uniqKey="Hernandez Sierra A" first="Astrid" last="Hernández-Sierra">Astrid Hernández-Sierra</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rovira, Jordi" sort="Rovira, Jordi" uniqKey="Rovira J" first="Jordi" last="Rovira">Jordi Rovira</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Petit, Anna" sort="Petit, Anna" uniqKey="Petit A" first="Anna" last="Petit">Anna Petit</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moya Rull, Daniel" sort="Moya Rull, Daniel" uniqKey="Moya Rull D" first="Daniel" last="Moya-Rull">Daniel Moya-Rull</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazuecos, Maria Auxiliadora" sort="Mazuecos, Maria Auxiliadora" uniqKey="Mazuecos M" first="María Auxiliadora" last="Mazuecos">María Auxiliadora Mazuecos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Universitario Puerta del Mar, Cadiz, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology, Hospital Universitario Puerta del Mar, Cadiz</wicri:regionArea>
<wicri:noRegion>Cadiz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez Fructuoso, Ana Isabel" sort="Sanchez Fructuoso, Ana Isabel" uniqKey="Sanchez Fructuoso A" first="Ana Isabel" last="Sánchez-Fructuoso">Ana Isabel Sánchez-Fructuoso</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology, Hospital Clinico San Carlos, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Errasti, Pedro" sort="Errasti, Pedro" uniqKey="Errasti P" first="Pedro" last="Errasti">Pedro Errasti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Clínica Universitaria de Navarra, Pamplona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology, Clínica Universitaria de Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Idoate, Miguel Ngel" sort="Idoate, Miguel Ngel" uniqKey="Idoate M" first="Miguel Ngel" last="Idoate">Miguel Ngel Idoate</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Clínica Universitaria de Navarra, Pamplona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology, Clínica Universitaria de Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cruzado, Josep Maria" sort="Cruzado, Josep Maria" uniqKey="Cruzado J" first="Josep María" last="Cruzado">Josep María Cruzado</name>
<affiliation wicri:level="3"><nlm:affiliation>Renal Transplant Unit, Hospital Universitari de Bellvitge, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Renal Transplant Unit, Hospital Universitari de Bellvitge, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vidal, August" sort="Vidal, August" uniqKey="Vidal A" first="August" last="Vidal">August Vidal</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Hospital Universitari de Bellvitge, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology, Hospital Universitari de Bellvitge, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diekmann, Fritz" sort="Diekmann, Fritz" uniqKey="Diekmann F" first="Fritz" last="Diekmann">Fritz Diekmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campistol, Josep M" sort="Campistol, Josep M" uniqKey="Campistol J" first="Josep M" last="Campistol">Josep M. Campistol</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Revuelta, Ignacio" sort="Revuelta, Ignacio" uniqKey="Revuelta I" first="Ignacio" last="Revuelta">Ignacio Revuelta</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27208691</idno>
<idno type="pmid">27208691</idno>
<idno type="doi">10.1111/tri.12800</idno>
<idno type="wicri:Area/Main/Corpus">000A49</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A49</idno>
<idno type="wicri:Area/Main/Curation">000A49</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A49</idno>
<idno type="wicri:Area/Main/Exploration">000A49</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.</title>
<author><name sortKey="Hernandez Sierra, Astrid" sort="Hernandez Sierra, Astrid" uniqKey="Hernandez Sierra A" first="Astrid" last="Hernández-Sierra">Astrid Hernández-Sierra</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rovira, Jordi" sort="Rovira, Jordi" uniqKey="Rovira J" first="Jordi" last="Rovira">Jordi Rovira</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Petit, Anna" sort="Petit, Anna" uniqKey="Petit A" first="Anna" last="Petit">Anna Petit</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moya Rull, Daniel" sort="Moya Rull, Daniel" uniqKey="Moya Rull D" first="Daniel" last="Moya-Rull">Daniel Moya-Rull</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazuecos, Maria Auxiliadora" sort="Mazuecos, Maria Auxiliadora" uniqKey="Mazuecos M" first="María Auxiliadora" last="Mazuecos">María Auxiliadora Mazuecos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Universitario Puerta del Mar, Cadiz, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology, Hospital Universitario Puerta del Mar, Cadiz</wicri:regionArea>
<wicri:noRegion>Cadiz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez Fructuoso, Ana Isabel" sort="Sanchez Fructuoso, Ana Isabel" uniqKey="Sanchez Fructuoso A" first="Ana Isabel" last="Sánchez-Fructuoso">Ana Isabel Sánchez-Fructuoso</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology, Hospital Clinico San Carlos, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Errasti, Pedro" sort="Errasti, Pedro" uniqKey="Errasti P" first="Pedro" last="Errasti">Pedro Errasti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Clínica Universitaria de Navarra, Pamplona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology, Clínica Universitaria de Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Idoate, Miguel Ngel" sort="Idoate, Miguel Ngel" uniqKey="Idoate M" first="Miguel Ngel" last="Idoate">Miguel Ngel Idoate</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Clínica Universitaria de Navarra, Pamplona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology, Clínica Universitaria de Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cruzado, Josep Maria" sort="Cruzado, Josep Maria" uniqKey="Cruzado J" first="Josep María" last="Cruzado">Josep María Cruzado</name>
<affiliation wicri:level="3"><nlm:affiliation>Renal Transplant Unit, Hospital Universitari de Bellvitge, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Renal Transplant Unit, Hospital Universitari de Bellvitge, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vidal, August" sort="Vidal, August" uniqKey="Vidal A" first="August" last="Vidal">August Vidal</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Hospital Universitari de Bellvitge, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology, Hospital Universitari de Bellvitge, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diekmann, Fritz" sort="Diekmann, Fritz" uniqKey="Diekmann F" first="Fritz" last="Diekmann">Fritz Diekmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campistol, Josep M" sort="Campistol, Josep M" uniqKey="Campistol J" first="Josep M" last="Campistol">Josep M. Campistol</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Revuelta, Ignacio" sort="Revuelta, Ignacio" uniqKey="Revuelta I" first="Ignacio" last="Revuelta">Ignacio Revuelta</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Transplant international : official journal of the European Society for Organ Transplantation</title>
<idno type="eISSN">1432-2277</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Female (MeSH)</term>
<term>Graft Survival (MeSH)</term>
<term>Herpesvirus 8, Human (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunosuppression (MeSH)</term>
<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Kidney Transplantation (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Multivariate Analysis (MeSH)</term>
<term>Neoplasm Recurrence, Local (MeSH)</term>
<term>Neoplasm Staging (methods)</term>
<term>PTEN Phosphohydrolase (metabolism)</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa (metabolism)</term>
<term>Sarcoma, Kaposi (metabolism)</term>
<term>Sarcoma, Kaposi (virology)</term>
<term>Spain (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Time Factors (MeSH)</term>
<term>Transforming Growth Factor beta (metabolism)</term>
<term>Vascular Endothelial Growth Factor A (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse multifactorielle (MeSH)</term>
<term>Espagne (MeSH)</term>
<term>Facteur de croissance endothéliale vasculaire de type A (métabolisme)</term>
<term>Facteur de croissance transformant bêta (métabolisme)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Herpèsvirus humain de type 8 (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunosuppresseurs (usage thérapeutique)</term>
<term>Immunosuppression thérapeutique (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Phosphohydrolase PTEN (métabolisme)</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa (métabolisme)</term>
<term>Récidive tumorale locale (MeSH)</term>
<term>Sarcome de Kaposi (métabolisme)</term>
<term>Sarcome de Kaposi (virologie)</term>
<term>Stadification tumorale (méthodes)</term>
<term>Sujet âgé (MeSH)</term>
<term>Survie du greffon (MeSH)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transplantation rénale (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>PTEN Phosphohydrolase</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Transforming Growth Factor beta</term>
<term>Vascular Endothelial Growth Factor A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Sarcoma, Kaposi</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neoplasm Staging</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term>
<term>Facteur de croissance transformant bêta</term>
<term>Phosphohydrolase PTEN</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa</term>
<term>Sarcome de Kaposi</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Stadification tumorale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Sarcome de Kaposi</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Sarcoma, Kaposi</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Graft Survival</term>
<term>Herpesvirus 8, Human</term>
<term>Humans</term>
<term>Immunosuppression</term>
<term>Kidney Transplantation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neoplasm Recurrence, Local</term>
<term>Spain</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse multifactorielle</term>
<term>Espagne</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Herpèsvirus humain de type 8</term>
<term>Humains</term>
<term>Immunosuppression thérapeutique</term>
<term>Mâle</term>
<term>Récidive tumorale locale</term>
<term>Sujet âgé</term>
<term>Survie du greffon</term>
<term>Transplantation rénale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Kaposi's sarcoma (KS) is one of the most frequent transplant related tumors. Several pathways are involved; however, the impact of the molecular phenotype associated to the tumor stage and the behavior-depending resultant therapy is still unknown. The aim of our study was to analyze the role of HHV-8 and mTOR pathway in tumor stages of skin KS after renal transplantation. Twelve renal transplant recipients with cutaneous KS from five transplant centers (1980-2007) under reduction of immunosuppression or conversion to mTOR inhibitor were included. The expression of HHV-8, PTEN, TGFβ, VEGF, phospho-mTOR, and phospho-P70S6K in tumoral tissue was analyzed. KS lesions were classified as patch, plaque, and nodule state. HHV-8 infection was found in all tissue samples. KS lesions showed high activation of VEGF, p-mTOR and p-P70S6K, low PTEN, and null TGFβ expression. The only pathway activated in a staging-dependent manner was mTOR with higher p-mTOR and p-P70S6K expression in nodule versus patch stage. KS lesions disappeared after 5.24 months in all converted patients without any recurrence in 14.05 years of mean follow-up. The activation of mTOR pathway according to KS stages supports the rational of the mTOR inhibitor in post-transplant Kaposi. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27208691</PMID>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-2277</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>29</Volume>
<Issue>9</Issue>
<PubDate><Year>2016</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Transplant international : official journal of the European Society for Organ Transplantation</Title>
<ISOAbbreviation>Transpl Int</ISOAbbreviation>
</Journal>
<ArticleTitle>Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.</ArticleTitle>
<Pagination><MedlinePgn>1008-16</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/tri.12800</ELocationID>
<Abstract><AbstractText>Kaposi's sarcoma (KS) is one of the most frequent transplant related tumors. Several pathways are involved; however, the impact of the molecular phenotype associated to the tumor stage and the behavior-depending resultant therapy is still unknown. The aim of our study was to analyze the role of HHV-8 and mTOR pathway in tumor stages of skin KS after renal transplantation. Twelve renal transplant recipients with cutaneous KS from five transplant centers (1980-2007) under reduction of immunosuppression or conversion to mTOR inhibitor were included. The expression of HHV-8, PTEN, TGFβ, VEGF, phospho-mTOR, and phospho-P70S6K in tumoral tissue was analyzed. KS lesions were classified as patch, plaque, and nodule state. HHV-8 infection was found in all tissue samples. KS lesions showed high activation of VEGF, p-mTOR and p-P70S6K, low PTEN, and null TGFβ expression. The only pathway activated in a staging-dependent manner was mTOR with higher p-mTOR and p-P70S6K expression in nodule versus patch stage. KS lesions disappeared after 5.24 months in all converted patients without any recurrence in 14.05 years of mean follow-up. The activation of mTOR pathway according to KS stages supports the rational of the mTOR inhibitor in post-transplant Kaposi. </AbstractText>
<CopyrightInformation>© 2016 Steunstichting ESOT.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hernández-Sierra</LastName>
<ForeName>Astrid</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rovira</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petit</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moya-Rull</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mazuecos</LastName>
<ForeName>María Auxiliadora</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario Puerta del Mar, Cadiz, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sánchez-Fructuoso</LastName>
<ForeName>Ana Isabel</ForeName>
<Initials>AI</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Errasti</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology, Clínica Universitaria de Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Idoate</LastName>
<ForeName>Miguel Ángel</ForeName>
<Initials>MÁ</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Clínica Universitaria de Navarra, Pamplona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cruzado</LastName>
<ForeName>Josep María</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Renal Transplant Unit, Hospital Universitari de Bellvitge, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vidal</LastName>
<ForeName>August</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Hospital Universitari de Bellvitge, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Diekmann</LastName>
<ForeName>Fritz</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oppenheimer</LastName>
<ForeName>Federico</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Campistol</LastName>
<ForeName>Josep M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Revuelta</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Fundació Clínic - IDIBAPS, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Transpl Int</MedlineTA>
<NlmUniqueID>8908516</NlmUniqueID>
<ISSNLinking>0934-0874</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016212">Transforming Growth Factor beta</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C467484">VEGFA protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D038762">Ribosomal Protein S6 Kinases, 70-kDa</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.67</RegistryNumber>
<NameOfSubstance UI="D051059">PTEN Phosphohydrolase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.67</RegistryNumber>
<NameOfSubstance UI="C494929">PTEN protein, human</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006085" MajorTopicYN="N">Graft Survival</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019288" MajorTopicYN="N">Herpesvirus 8, Human</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016030" MajorTopicYN="Y">Kidney Transplantation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051059" MajorTopicYN="N">PTEN Phosphohydrolase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D038762" MajorTopicYN="N">Ribosomal Protein S6 Kinases, 70-kDa</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012514" MajorTopicYN="N">Sarcoma, Kaposi</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016212" MajorTopicYN="N">Transforming Growth Factor beta</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">post-transplant malignancy</Keyword>
<Keyword MajorTopicYN="N">rapamycin</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>01</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>02</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>05</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>5</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>5</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>8</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27208691</ArticleId>
<ArticleId IdType="doi">10.1111/tri.12800</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
<li>Communauté de Madrid</li>
</region>
<settlement><li>Barcelone</li>
<li>Madrid</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Hernandez Sierra, Astrid" sort="Hernandez Sierra, Astrid" uniqKey="Hernandez Sierra A" first="Astrid" last="Hernández-Sierra">Astrid Hernández-Sierra</name>
</region>
<name sortKey="Campistol, Josep M" sort="Campistol, Josep M" uniqKey="Campistol J" first="Josep M" last="Campistol">Josep M. Campistol</name>
<name sortKey="Campistol, Josep M" sort="Campistol, Josep M" uniqKey="Campistol J" first="Josep M" last="Campistol">Josep M. Campistol</name>
<name sortKey="Cruzado, Josep Maria" sort="Cruzado, Josep Maria" uniqKey="Cruzado J" first="Josep María" last="Cruzado">Josep María Cruzado</name>
<name sortKey="Diekmann, Fritz" sort="Diekmann, Fritz" uniqKey="Diekmann F" first="Fritz" last="Diekmann">Fritz Diekmann</name>
<name sortKey="Diekmann, Fritz" sort="Diekmann, Fritz" uniqKey="Diekmann F" first="Fritz" last="Diekmann">Fritz Diekmann</name>
<name sortKey="Errasti, Pedro" sort="Errasti, Pedro" uniqKey="Errasti P" first="Pedro" last="Errasti">Pedro Errasti</name>
<name sortKey="Hernandez Sierra, Astrid" sort="Hernandez Sierra, Astrid" uniqKey="Hernandez Sierra A" first="Astrid" last="Hernández-Sierra">Astrid Hernández-Sierra</name>
<name sortKey="Idoate, Miguel Ngel" sort="Idoate, Miguel Ngel" uniqKey="Idoate M" first="Miguel Ngel" last="Idoate">Miguel Ngel Idoate</name>
<name sortKey="Mazuecos, Maria Auxiliadora" sort="Mazuecos, Maria Auxiliadora" uniqKey="Mazuecos M" first="María Auxiliadora" last="Mazuecos">María Auxiliadora Mazuecos</name>
<name sortKey="Moya Rull, Daniel" sort="Moya Rull, Daniel" uniqKey="Moya Rull D" first="Daniel" last="Moya-Rull">Daniel Moya-Rull</name>
<name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name>
<name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name>
<name sortKey="Petit, Anna" sort="Petit, Anna" uniqKey="Petit A" first="Anna" last="Petit">Anna Petit</name>
<name sortKey="Revuelta, Ignacio" sort="Revuelta, Ignacio" uniqKey="Revuelta I" first="Ignacio" last="Revuelta">Ignacio Revuelta</name>
<name sortKey="Revuelta, Ignacio" sort="Revuelta, Ignacio" uniqKey="Revuelta I" first="Ignacio" last="Revuelta">Ignacio Revuelta</name>
<name sortKey="Rovira, Jordi" sort="Rovira, Jordi" uniqKey="Rovira J" first="Jordi" last="Rovira">Jordi Rovira</name>
<name sortKey="Sanchez Fructuoso, Ana Isabel" sort="Sanchez Fructuoso, Ana Isabel" uniqKey="Sanchez Fructuoso A" first="Ana Isabel" last="Sánchez-Fructuoso">Ana Isabel Sánchez-Fructuoso</name>
<name sortKey="Vidal, August" sort="Vidal, August" uniqKey="Vidal A" first="August" last="Vidal">August Vidal</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A24 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A24 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27208691
   |texte=   Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27208691" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.

Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki